Hepatology

Zonulin is a human protein that modulates the permeability of tight junctions between cells of the digestive tract. It plays a key role in maintaining the integrity of the intestinal barrier and its dysregulation has been linked to increased intestinal permeability or "leaky gut," which can allow toxins and antigens to enter the bloodstream. Elevated zonulin levels are associated with various autoimmune and inflammatory conditions, such as celiac disease, type 1 diabetes, and irritable bowel syndrome. As a therapeutic target,zonulin is of growing interest for interventions aimed at restoring gut barrier function and managing chronic inflammatory disease